Validity and reliability of high-resolution ultrasound imaging for the assessment of regional body composition in stage 5 chronic kidney disease patients undergoing continuous ambulatory peritoneal dialysis | Zendy

Louise Geneen | Zendy; Jodie Kinsella | Zendy; Tobia Zanotto | Zendy; P. Naish | Zendy; Thomas H. Mercer | Zendy

Open Access

Validity and reliability of high-resolution ultrasound imaging for the assessment of regional body composition in stage 5 chronic kidney disease patients undergoing continuous ambulatory peritoneal dialysis

Author(s) -

Louise Geneen,

Jodie Kinsella,

Tobia Zanotto,

P. Naish,

Thomas H. Mercer

Publication year - 2021

Publication title -

peritoneal dialysis international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.79

H-Index - 83

eISSN - 1718-4304

pISSN - 0896-8608

DOI - 10.1177/08968608211002384

Subject(s) - medicine , gold standard (test) , population , intraclass correlation , magnetic resonance imaging , kidney disease , continuous ambulatory peritoneal dialysis , ultrasound , standard error , peritoneal dialysis , intra rater reliability , hydrostatic weighing , radiology , nuclear medicine , surgery , physical therapy , body weight , clinical psychology , confidence interval , statistics , environmental health , mathematics , psychometrics

Background: Accurate measurement of muscle mass is an important research and clinical tool. High-resolution ultrasound (US) has shown potential as a method to assess muscle and fat mass at specific anatomical sites. However, there is limited evidence for the reliability of US to measure muscle size in patients receiving continuous ambulatory peritoneal dialysis (CAPD). Therefore, we examined the validity and reliability of an US method compared to a gold standard comparison for the assessment of a quadriceps muscle in this clinical population.Methods: Twenty people receiving CAPD (mean age = 56.5 ± 16.7 years) at a single dialysis unit were assessed on two occasions, 7 days apart. Measures of the mid-thigh, such as vastus lateralis (VL) anatomical cross-sectional area (ACSA), VL muscle thickness and subcutaneous fat thickness were compared for US reliability and validity compared to magnetic resonance imaging (MRI) measures.Results: US had high validity against gold standard MRI measures, with intraclass correlation coefficients (ICC) equating to VL ACSA of 0.95, VL thickness of 0.99 and fat thickness of 0.98. The US measurements also exhibited high intra-rater reliability (ICCs: VL thickness = 0.98, total muscle thickness = 0.97 and fat thickness = 0.99) in measuring body composition at the mid-VL site in the study population.Conclusions: Valid assessment of regional body composition can be achieved via high-resolution US in patients receiving CAPD. The validity and reliability of the US in repeated measures (in comparison to the gold standard MRI) warrant further investigation in the wider chronic kidney disease population.

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