Open AccessAlterations in Oral Microbiota in HIV Are Related to Decreased Pulmonary Function
Author(s) -
Liheng Yang,
D.G. Dunlap,
Shulin Qin,
Adam Fitch,
Kelvin Li,
Carl Koch,
Mehdi Nouraie,
Rebecca DeSensi,
Ken Ho,
Jeremy Martinson,
Barbara Methé,
Alison Morris
Publication year - 2020
Publication title -
american journal of respiratory and critical care medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.272
H-Index - 374
eISSN - 1535-4970
pISSN - 1073-449X
DOI - 10.1164/rccm.201905-1016oc
Subject(s) - microbiome , copd , medicine , immunology , oral microbiome , dysbiosis , saliva , lung , obstructive lung disease , biomarker , pulmonary function testing , streptococcus , gut flora , disease , biology , bioinformatics , genetics , bacteria
Rationale: Mechanisms of HIV-associated chronic obstructive pulmonary disease (COPD) are poorly understood. The oral microbiome shapes the lung microbiome, and gut dysbiosis can affect lung diseases; however, relationships of the oral and gut microbiome to COPD in HIV have not been explored. Objectives: To examine alterations in the oral and gut microbiome associated with pulmonary disease in persons with HIV (PWH). Methods: Seventy-five PWH and 93 HIV-uninfected men from the MACS (Multicenter AIDS Cohort Study) performed pulmonary function testing. Sequencing of bacterial 16S ribosomal RNA in saliva and stool was performed. We used nonmetric multidimensional scaling, permutational multivariate ANOVA, and linear discriminant analysis to analyze communities by HIV and lung function. Measurements and Main Results: Oral microbiome composition differed by HIV and smoking status. Alterations of oral microbial communities were observed in PWH with abnormal lung function with increases in relative abundance of Veillonella , Streptococcus , and Lactobacillus . There were no significant associations between the oral microbiome and lung function in HIV-uninfected individuals. No associations with HIV status or lung function were seen with the gut microbiome. Conclusions: Alterations of oral microbiota in PWH were related to impaired pulmonary function and to systemic inflammation. These results suggest that the oral microbiome may serve as a biomarker of lung function in HIV and that its disruption may contribute to COPD pathogenesis.