Role of Genetic Variation in Collateral Circulation in the Evolution of Acute Stroke | Zendy

YuChieh Jill Kao | Zendy; Esteban A. Oyarzabal | Zendy; Hua Zhang | Zendy; James E. Faber | Zendy; YenYu Ian Shih | Zendy

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Role of Genetic Variation in Collateral Circulation in the Evolution of Acute Stroke

Author(s) -

YuChieh Jill Kao,

Esteban A. Oyarzabal,

Hua Zhang,

James E. Faber,

YenYu Ian Shih

Publication year - 2017

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.116.015878

Subject(s) - medicine , collateral circulation , stroke (engine) , collateral , acute stroke , circulation (fluid dynamics) , cardiology , variation (astronomy) , tissue plasminogen activator , mechanical engineering , engineering , physics , finance , astrophysics , economics , thermodynamics

No studies have determined the effect of differences in pial collateral extent (number and diameter), independent of differences in environmental factors and unknown genetic factors, on severity of stroke. We examined ischemic tissue evolution during acute stroke, as measured by magnetic resonance imaging and histology, by comparing 2 congenic mouse strains with otherwise identical genetic backgrounds but with different alleles of the Determinant of collateral extent-1 ( Dce1 ) genetic locus. We also optimized magnetic resonance perfusion and diffusion-deficit thresholds by using histological measures of ischemic tissue.

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