Effect of Angiotensin-Converting Enzyme Inhibition and Angiotensin II Receptor Blockers on Cardiac Angiotensin-Converting Enzyme 2 | Zendy

Carlos M. Ferrario | Zendy; Jewell A. Jessup | Zendy; Mark C. Chappell | Zendy; David B. Averill | Zendy; K. Bridget Brosnihan | Zendy; E. Ann Tallant | Zendy; Debra I. Diz | Zendy; Patricia E. Gallagher | Zendy

Open Access

Effect of Angiotensin-Converting Enzyme Inhibition and Angiotensin II Receptor Blockers on Cardiac Angiotensin-Converting Enzyme 2

Author(s) -

Carlos M. Ferrario,

Jewell A. Jessup,

Mark C. Chappell,

David B. Averill,

K. Bridget Brosnihan,

E. Ann Tallant,

Debra I. Diz,

Patricia E. Gallagher

Publication year - 2005

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.104.510461

Subject(s) - losartan , lisinopril , angiotensin ii , medicine , endocrinology , angiotensin converting enzyme 2 , cardiac function curve , angiotensin converting enzyme , neprilysin , renin–angiotensin system , ace inhibitor , blood pressure , pharmacology , heart failure , enzyme , chemistry , biochemistry , disease , covid-19 , infectious disease (medical specialty)

Angiotensin-converting enzyme 2 (ACE2) has emerged as a novel regulator of cardiac function and arterial pressure by converting angiotensin II (Ang II) into the vasodilator and antitrophic heptapeptide, angiotensin-(1-7) [Ang-(1-7)]. As the only known human homolog of ACE, the demonstration that ACE2 is insensitive to blockade by ACE inhibitors prompted us to define the effect of ACE inhibition on the ACE2 gene.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research