Genetic Analysis Reveals a Longevity-Associated Protein Modulating Endothelial Function and Angiogenesis | Zendy

Francesco Villa | Zendy; Albino Carrizzo | Zendy; Chiara Spinelli | Zendy; Anna Ferrario | Zendy; Alberto Malovini | Zendy; Anna Maciąg | Zendy; Antonio Damato | Zendy; Alberto Auricchio | Zendy; Gaia Spinetti | Zendy; Elena Sangalli | Zendy; Zexu Dang | Zendy; Michele Madonna | Zendy; Mariateresa Ambrosio | Zendy; Leopoldo Sitia | Zendy; Paolo Bigini | Zendy; Gaetano Calı̀ | Zendy; Stefan Schreiber | Zendy; Thomas T. Perls | Zendy; Sergio Fucile | Zendy; Francesca Mulas | Zendy; Almut Nebel | Zendy; Riccardo Bellazzi | Zendy; Paolo Madeddu | Zendy; Carmine Vecchione | Zendy; Annibale Alessandro Puca | Zendy

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Genetic Analysis Reveals a Longevity-Associated Protein Modulating Endothelial Function and Angiogenesis

Author(s) -

Francesco Villa,

Albino Carrizzo,

Chiara Spinelli,

Anna Ferrario,

Alberto Malovini,

Anna Maciąg,

Antonio Damato,

Alberto Auricchio,

Gaia Spinetti,

Elena Sangalli,

Zexu Dang,

Michele Madonna,

Mariateresa Ambrosio,

Leopoldo Sitia,

Paolo Bigini,

Gaetano Calı̀,

Stefan Schreiber,

Thomas T. Perls,

Sergio Fucile,

Francesca Mulas,

Almut Nebel,

Riccardo Bellazzi,

Paolo Madeddu,

Carmine Vecchione,

Annibale Alessandro Puca

Publication year - 2015

Publication title -

circulation research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.899

H-Index - 336

eISSN - 1524-4571

pISSN - 0009-7330

DOI - 10.1161/circresaha.117.305875

Subject(s) - biology , endothelial dysfunction , longevity , angiogenesis , microbiology and biotechnology , endothelium , progenitor cell , unfolded protein response , stem cell , homeostasis , endoplasmic reticulum , endocrinology , cancer research , genetics

Long living individuals show delay of aging, which is characterized by the progressive loss of cardiovascular homeostasis, along with reduced endothelial nitric oxide synthase activity, endothelial dysfunction, and impairment of tissue repair after ischemic injury.

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