Dual Manganese-Enhanced and Delayed Gadolinium-Enhanced MRI Detects Myocardial Border Zone Injury in a Pig Ischemia-Reperfusion Model | Zendy

Rajesh Dash | Zendy; Jaehoon Chung | Zendy; Fumiaki Ikeno | Zendy; Annett Hahn-Windgassen | Zendy; Yuka Matsuura | Zendy; Mihoko V. Bennett | Zendy; Jennifer Lyons | Zendy; Tomohiko Teramoto | Zendy; Robert C. Robbins | Zendy; Michael V. McConnell | Zendy; Alan C. Yeung | Zendy; Todd J. Brinton | Zendy; Phillip Harnish | Zendy; Phillip C. Yang | Zendy

Open Access

Dual Manganese-Enhanced and Delayed Gadolinium-Enhanced MRI Detects Myocardial Border Zone Injury in a Pig Ischemia-Reperfusion Model

Author(s) -

Rajesh Dash,

Jaehoon Chung,

Fumiaki Ikeno,

Annett Hahn-Windgassen,

Yuka Matsuura,

Mihoko V. Bennett,

Jennifer Lyons,

Tomohiko Teramoto,

Robert C. Robbins,

Michael V. McConnell,

Alan C. Yeung,

Todd J. Brinton,

Phillip Harnish,

Phillip C. Yang

Publication year - 2011

Publication title -

circulation cardiovascular imaging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.584

H-Index - 99

eISSN - 1942-0080

pISSN - 1941-9651

DOI - 10.1161/circimaging.110.960591

Subject(s) - gadolinium , myocardial ischemia , border zone , cardiology , manganese , reperfusion injury , ischemia , dual (grammatical number) , medicine , chemistry , myocardial infarction , organic chemistry , art , literature

Gadolinium (Gd)-based delayed-enhancement MRI (DEMRI) identifies nonviable myocardium but is nonspecific and may overestimate nonviable territory. Manganese (Mn(2+))-enhanced MRI (MEMRI) denotes specific Mn(2+) uptake into viable cardiomyocytes. We performed a dual-contrast myocardial assessment in a porcine ischemia-reperfusion (IR) model to test the hypothesis that combined DEMRI and MEMRI identifies viable infarct border zone (BZ) myocardium in vivo.

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