ABCA1 (ATP-Binding Cassette Transporter A1) Mediates ApoA-I (Apolipoprotein A-I) and ApoA-I Mimetic Peptide Mobilization of Extracellular Cholesterol Microdomains Deposited by Macrophages | Zendy

Xueting Jin | Zendy; Denis Sviridov | Zendy; Ying Liu | Zendy; Boris Vaisman | Zendy; Lia Addadi | Zendy; Alan T. Remaley | Zendy; Howard S. Kruth | Zendy

Open Access

ABCA1 (ATP-Binding Cassette Transporter A1) Mediates ApoA-I (Apolipoprotein A-I) and ApoA-I Mimetic Peptide Mobilization of Extracellular Cholesterol Microdomains Deposited by Macrophages

Author(s) -

Xueting Jin,

Denis Sviridov,

Ying Liu,

Boris Vaisman,

Lia Addadi,

Alan T. Remaley,

Howard S. Kruth

Publication year - 2016

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.116.308334

Subject(s) - abca1 , sphingomyelin , cholesterol , extracellular , lipid microdomain , phospholipid , reverse cholesterol transport , biochemistry , atp binding cassette transporter 1 , apolipoprotein b , biology , microbiology and biotechnology , chemistry , transporter , lipoprotein , membrane , gene

We examined the function of ABCA1 (ATP-binding cassette transporter A1) in ApoA-I (apolipoprotein A-I) mobilization of cholesterol microdomains deposited into the extracellular matrix by cholesterol-enriched macrophages. We have also determined whether an ApoA-I mimetic peptide without and with complexing to sphingomyelin can mobilize macrophage-deposited cholesterol microdomains.

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