Open AccessCompartmentalized Protective and Detrimental Effects of Endogenous Macrophage Migration-Inhibitory Factor Mediated by CXCR2 in a Mouse Model of Myocardial Ischemia/Reperfusion
Author(s) -
Elisa A. Liehn,
Isabella Kanzler,
Simone Konschalla,
Andreas Kroh,
Sakine Simsekyilmaz,
Tolga Taha Sönmez,
Richard Bucala,
Jürgen Bernhagen,
Christian Weber
Publication year - 2013
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.113.301633
Subject(s) - cxc chemokine receptors , macrophage migration inhibitory factor , chemokine , medicine , endocrinology , chemokine receptor , cytokine , bone marrow , immunology , receptor
Here, we aimed to clarify the role of CXC chemokine receptor (CXCR) 2 in macrophage migration-inhibitory factor (MIF)-mediated effects after myocardial ischemia and reperfusion. As a pleiotropic chemokine-like cytokine, MIF has been identified to activate multiple receptors, including CD74 and CXCR2. In models of myocardial infarction, MIF exerts both proinflammatory effects and protective effects in cardiomyocytes. Similarly, CXCR2 displays opposing effects in resident versus circulating cells.
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