6-Mercaptopurine Inhibits Atherosclerosis in Apolipoprotein E*3-Leiden Transgenic Mice Through Atheroprotective Actions on Monocytes and Macrophages | Zendy

Thijs W.H. Pols | Zendy; Peter I. Bonta | Zendy; Nuno Pires | Zendy; Iker Otermin | Zendy; Mariska Vos | Zendy; Margreet R. de Vries | Zendy; Marco van Eijk | Zendy; Jeroen Roelofsen | Zendy; Louis M. Havekes | Zendy; Paul H.A. Quax | Zendy; André B. P. Kuilenburg | Zendy; Vivian de Waard | Zendy; Hans Pannekoek | Zendy; Carlie J.M. de Vries | Zendy

Open Access

6-Mercaptopurine Inhibits Atherosclerosis in Apolipoprotein E*3-Leiden Transgenic Mice Through Atheroprotective Actions on Monocytes and Macrophages

Author(s) -

Thijs W.H. Pols,

Peter I. Bonta,

Nuno Pires,

Iker Otermin,

Mariska Vos,

Margreet R. de Vries,

Marco van Eijk,

Jeroen Roelofsen,

Louis M. Havekes,

Paul H.A. Quax,

André B. P. Kuilenburg,

Vivian de Waard,

Hans Pannekoek,

Carlie J.M. de Vries

Publication year - 2010

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.110.205674

Subject(s) - genetically modified mouse , apolipoprotein e , macrophage , apolipoprotein b , chemistry , transgene , biology , medicine , biochemistry , cholesterol , gene , in vitro , disease

6-Mercaptopurine (6-MP), the active metabolite of the immunosuppressive prodrug azathioprine, is commonly used in autoimmune diseases and transplant recipients, who are at high risk for cardiovascular disease. Here, we aimed to gain knowledge on the action of 6-MP in atherosclerosis, with a focus on monocytes and macrophages.

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