Cognitive Deficits After Focal Cerebral Ischemia in Mice | Zendy

Kimihiko Hattori | Zendy; Hanna Lee | Zendy; Patricia D. Hurn | Zendy; Barbara J. Crain | Zendy; Richard J. Traystman | Zendy; A. Courtney DeVries | Zendy

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Cognitive Deficits After Focal Cerebral Ischemia in Mice

Author(s) -

Kimihiko Hattori,

Hanna Lee,

Patricia D. Hurn,

Barbara J. Crain,

Richard J. Traystman,

A. Courtney DeVries

Publication year - 2000

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.31.8.1939

Subject(s) - medicine , sham surgery , cohort , cresyl violet , stroke (engine) , ischemia , anesthesia , occlusion , cognition , pathology , staining , mechanical engineering , psychiatry , engineering , alternative medicine

The interpretation of cognitive data in many experimental stroke studies is problematic because middle cerebral artery occlusion (MCAO) is associated with sensorimotor alterations that may become confounding factors in cognitive testing. The purpose of the current study was to determine if it is possible to measure MCAO-induced cognitive deficits by using short durations of ischemia that do not result in alterations in sensorimotor behavior in mice.

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