Open AccessAltered Function of Inward Rectifier Potassium Channels in Cerebrovascular Smooth Muscle After Ischemia/Reperfusion
Author(s) -
Sean P. Marrelli,
T. David Johnson,
Andrei Khorovets,
W.F. Childres,
Robert M. Bryan
Publication year - 1998
Publication title -
stroke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.397
H-Index - 319
eISSN - 1524-4628
pISSN - 0039-2499
DOI - 10.1161/01.str.29.7.1469
Subject(s) - medicine , dilator , inward rectifier potassium ion channel , ischemia , cerebral arteries , isoflurane , anatomy , anesthesia , potassium channel , endocrinology , vascular smooth muscle , vasodilation , middle cerebral artery , potassium , smooth muscle , chemistry , receptor , organic chemistry , ion channel
Several recent studies have demonstrated that inward rectifier potassium channels (K(ir)s) are located on vascular smooth muscle of cerebral arteries in the rat. Activation of the K(ir)s dilates the arteries by relaxing the vascular smooth muscle. We tested the following hypothesis in the present study: function of inward rectifier potassium channels is altered after ischemia/reperfusion (I/R).
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom