Open AccessVentricular Function
Author(s) -
Erik Berglund,
Stanley J. Sarnoff,
James P. Isaacs
Publication year - 1955
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/01.res.3.2.133
Subject(s) - pericardium , ventricle , cardiology , medicine , regurgitation (circulation) , frank–starling law of the heart , ventricular function , circulatory system , ventricular pressure , diastole , preload , blood pressure , hemodynamics , stroke volume , heart rate
The influence of the pericardium on cardiovascular phenomena has been examined and evaluated in the light of both ventricular function (modified Starling) curves and pressure-volume relationship of the pericardium. When the left ventricle is stressed, as by an increased aortic resistance, it dilates. The resulting pericardial tension limits right ventricular diastolic expansion and right ventricular work. By this mechanism pulmonary blood volume and pressures are kept at lower levels than would otherwise be present. The pericardium also protects against ventriculo-atrial regurgitation which may account for the observed descending limb of the classically conceived Starling curve.
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