Renin Concentration of Normotensive and Hypertensive Dog Kidney

This report relates blood pressure, serum antirenin titer, and renal renin concentration in normotensive, acute and chronic experimental renal hypertensive, and spontaneous hypertensive dogs sacrificed at different levels of neutralizing antibody (antirenin) produced by injections of hog kidney extracts containing renin. Sufficient levels of antirenin can prevent or lower the blood pressure elevations secondary to partial constriction of the renal arteries in the dog. A highly significant relationship and correlation was found between increasing titer of antirenin and renal renin concentrations in both normotensive and hypertensive dogs. Two dogs not developing antirenin, although injected for many months with hog renins, did not have a renal renin concentration above control level. Goats treated with hog renin developed high antirenin titers but did not have an increase in renal renin. The goat differs from the dog, as does the monkey and man, in that antirenin produced from hog or dog renins does not neutralize the endogenous renin of the animal. It is concluded that the increase in renal renin found in these experiments is related directly to the presence of antirenin which is capable of neutralizing the endogenous renin of the experimental animal.