Angiotensin-converting enzyme, bradykinin, angiotensin, and cerebral vessel reactivity. | Zendy

Eric T. Whalley | Zendy; Michael Wahl | Zendy; Cláudio A.M. Sampaio | Zendy

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Angiotensin-converting enzyme, bradykinin, angiotensin, and cerebral vessel reactivity.

Author(s) -

Eric T. Whalley,

Michael Wahl,

Cláudio A.M. Sampaio

Publication year - 1983

Publication title -

hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.986

H-Index - 265

eISSN - 1524-4563

pISSN - 0194-911X

DOI - 10.1161/01.hyp.5.6_pt_3.v34

Subject(s) - bradykinin , medicine , endocrinology , cycloheximide , angiotensin converting enzyme , renin–angiotensin system , angiotensin ii , cerebral arteries , chemistry , basilar artery , enzyme , blood vessel , vasodilation , biochemistry , blood pressure , receptor , protein biosynthesis

Bradykinin (BK) produced concentration-related relaxations of cat middle cerebral arteries and was ineffective in cat basilar arteries. On rabbit basilar arteries, BK initially produced concentration-related relaxations; however, when repeated at 2-hour intervals, BK eventually produced pure contractile responses. After preincubation of the tissues with cycloheximide, BK produced reproducible relaxation responses. The angiotensin-converting enzyme inhibitors, SQ 14,225, BPP5a, and BPP9a, had no effect on the concentration-effect curves of BK, AII, or 5-HT with any of the preparations, but responses to AI were inhibited. These results suggest that, in these tissues, angiotensin-converting enzyme is important for conversion of AI to AII, but apparently not for the degradation of BK.

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