Role of endothelium in the maintenance of low pulmonary vascular tone in normal children. | Zendy

David S. Celermajer | Zendy; C Dollery | Zendy; M. Burch | Zendy; John Deanfield | Zendy

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Role of endothelium in the maintenance of low pulmonary vascular tone in normal children.

Author(s) -

David S. Celermajer,

C Dollery,

M. Burch,

John Deanfield

Publication year - 1994

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.89.5.2041

Subject(s) - dilator , medicine , cardiology , vascular resistance , pulmonary artery , vasodilation , hemodynamics , endothelium derived relaxing factor , left pulmonary artery , circulatory system , endothelium , anesthesia

Resting vascular tone is low in the normal pulmonary circulation, and experimental studies have suggested that this may be due to the continuous release of endothelium-derived nitric oxide (NO), a locally acting vasodilator. We have investigated whether NO contributes to the normal control of pulmonary vascular tone and resistance in children.

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