Macrophage Low-Density Lipoprotein Receptor-Related Protein Deficiency Enhances Atherosclerosis in ApoE/LDLR Double Knockout Mice | Zendy

Lu Hu | Zendy; Lianne S.M. Boesten | Zendy; P. May | Zendy; Joachim Herz | Zendy; Niels Bovenschen | Zendy; Menno V. Huisman | Zendy; Jimmy F.P. Berbée | Zendy; Louis M. Havekes | Zendy; Bart J.M. van Vlijmen | Zendy; J.T. Tamsma | Zendy

Open Access

Macrophage Low-Density Lipoprotein Receptor-Related Protein Deficiency Enhances Atherosclerosis in ApoE/LDLR Double Knockout Mice

Author(s) -

Lu Hu,

Lianne S.M. Boesten,

P. May,

Joachim Herz,

Niels Bovenschen,

Menno V. Huisman,

Jimmy F.P. Berbée,

Louis M. Havekes,

Bart J.M. van Vlijmen,

J.T. Tamsma

Publication year - 2006

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/01.atv.0000249641.96896.e6

Subject(s) - ldl receptor , macrophage , apolipoprotein e , monocyte , lipoprotein , endocrinology , medicine , knockout mouse , receptor , cholesterol , low density lipoprotein , biology , chemistry , in vitro , biochemistry , disease

In vitro studies implicate that the low-density lipoprotein receptor (LDLR)-related protein (LRP) in macrophages has a pro-atherogenic potential. In the present study, we investigated the in vivo role of macrophage specific LRP in atherogenesis independent of its role in the uptake of lipoproteins.

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