Activity of antioxidant enzymes and gelatinase in rats with epinephrine-induced miocardial ischemia | Zendy

V. A. Parоnik | Zendy; O. E. Shaul’ska | Zendy; V. I. Zhylіuk | Zendy; А. И. Шевцова | Zendy

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Activity of antioxidant enzymes and gelatinase in rats with epinephrine-induced miocardial ischemia

Author(s) -

V. A. Parоnik,

O. E. Shaul’ska,

V. I. Zhylіuk,

А. И. Шевцова

Publication year - 2015

Publication title -

medical and clinical chemistry

Language(s) - English

Resource type - Journals

eISSN - 2414-9934

pISSN - 2410-681X

DOI - 10.11603/mcch.2410-681x.2015.v17.i3.5055

Subject(s) - gelatinases , epinephrine , antioxidant , chemistry , enzyme , lipid peroxidation , ischemia , endocrinology , medicine , pharmacology , gelatinase , biochemistry

In this study we examined the activity of antioxidant enzymes and gelatinases in rats with epinephrine-induced myocardial ischemia and the impact of corvitin (C) and doxycycline (D) on these indicators. The administration of epinephrine (0.2 mg/100 g) for 10 days leads to an increase in lipid peroxidation and to the elevated activity of antioxidant enzymes and gelatinases in blood and in the heart of experimental animals. Under application of C and D activity of the enzymes was reduced, especially activity of SOD and gelatinases. Our data suggest that C and D can reduce the cardiotoxic effects of high doses of epinephrine due to their ability to bind free radicals and to inhibit the activity of matrix-degrading enzymes.

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