ЕНДОТЕЛІАЛЬНІ Й ІМУНОЛОГІЧНІ ЗМІНИ ПРИ КОМПРЕСІЙНО-ІШЕМІЧНІЙ РАДИКУЛОМІЄЛОПАТІЇ ТА ЇХ ЕНЕРГЕТИЧНА КОРЕКЦІЯ

The pathological process of compression-ischemic radiculomyelopathy (CIRMP ) is accompanied by high energy costs. Therefore, topical is the use of drugs that improve energy metabolism in hypoxic conditions.The aim of the study – to investigate the features of the immuno-inflammatory process in CIRMP under the influence of meldonium.Materials and Methods. The parameters of 45 patients with CIRMP were investigated. All patients received conventional therapy. Patients of the group 1 (26 patients) received meldonium additionally, and in the group 2 (the main one – 19 patients) included "capicor". The levels of endothelin-1, cGMP , NO , interleukin-1β and -4, tumor necrosis factor-α were studied, aggregation properties of platelets were studied.Results and Discussion. Against the background of the treatment of patients with the use of meldonium and meldonium+γ-butyrobetan dihydrate, positive changes in the biochemical parameters: endothelin-1, cGMP , NO , interleukins 1β and 4, tumor necrosis factor α, aggregation properties of platelets, improvement of the function of the endothelium and blood circulation in the microvessels of the rootlets, which, in turn, led to the restoration of the functional state of roots and spinal cord.Conclusions. The use of meldonium and meldonium+γ-butyrobetaine in the therapy of patients with CIRMP was accompanied by a regression of clinical manifestations, which is associated with an improvement in blood circulation in the vessels of the spinal roots and back muscles. A more pronounced effect was influenced by meldonium in combination with γ-butyrobetaine.