Open AccessCytomegalovirus Infection Is a Risk Factor in Gastrointestinal Cancer: A Cross-Sectional and Meta-Analysis Study
Author(s) -
Yali Lv,
Feifei Han,
Zhuoling An,
Yangjie Jia,
Lingling Xuan,
Lili Gong,
Wen Zhang,
Lulu Ren,
Song Yang,
Liu He,
Lihong Liu
Publication year - 2020
Publication title -
intervirology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.641
H-Index - 61
eISSN - 1423-0100
pISSN - 0300-5526
DOI - 10.1159/000506683
Subject(s) - human cytomegalovirus , medicine , cross sectional study , immunology , risk factor , colorectal cancer , cytomegalovirus , gastroenterology , case control study , cancer , herpesviridae , virus , viral disease , pathology
Background: This study was planned to investigate the association between human cytomegalovirus (HCMV) infection and gastrointestinal cancer (GIC) risk, by undertaking a meta-analysis and case-control cross-sectional study. Summary: A cross-sectional study analysis of 160 GIC patients and 100 control subjects indicated significantly higher HCMV prevalence in GIC patients based on the HCMV IgM test. However, a similar analysis based on an IgG test revealed no significant relationship. Further meta-analysis of 11 studies, including 1,044 patients and 991 healthy subjects, displayed HCMV infection as an important risk factor for not only colorectal cancer occurrence and development based on a HCMV DNA test, but also for GIC based on a HCMV IgM test. However, the IgG test again displayed no significant relationship between HCMV infection and GIC occurrence. Key Message: Overall, our study revealed that HCMV infection is associated with an increased GIC risk. However, additional studies are warranted to elucidate the molecular mechanism underlying this association.