Open AccessUp-Regulation of Na+/Ca2+ Exchange in Megakaryocytes Following TGFβ1 Treatment
Author(s) -
Ahmad Almilaji,
Jing Yan,
Zohreh Hosseinzadeh,
Evi Schmid,
Meinrad Gawaz,
Florian Läng
Publication year - 2016
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000445660
Subject(s) - orai1 , extracellular , cytosol , chemistry , intracellular , microbiology and biotechnology , stim1 , sodium calcium exchanger , transforming growth factor , megakaryocyte , platelet , biophysics , endoplasmic reticulum , medicine , biochemistry , biology , stem cell , progenitor cell , enzyme
Blood platelets are activated by increase of cytosolic Ca2+ activity ([Ca2+]i). Ca2+ entry is accomplished in part by store operated Ca2+ entry (SOCE) involving Ca2+ release activated Ca2+-channel (CRAC) moiety Orai1 and its regulator STIM1, which are stimulated by depletion of intracellular Ca2+ stores. An increase of [Ca2+]i is terminated by Na+/Ca2+-exchange. The expression of both, Orai1 and STIM1 in megakaryocytes is up-regulated by tumor growth factor TGFβ1, a powerful regulator of megakaryocyte differentiation. The present study explored whether TGFβ1 similarly modifies megakaryocyte Na+/Ca2+-exchanger activity.
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