Open AccessRadiation with STAT3 Blockade Triggers Dendritic Cell–T cell Interactions in the Glioma Microenvironment and Therapeutic Efficacy
Author(s) -
Martina Ott,
Cynthia Kassab,
Anantha Marisetty,
Yuichi Hashimoto,
Jun Wei,
Daniel Zamler,
Jia-Shiun Leu,
Karl Heinz Tomaszowski,
Aria Sabbagh,
Dexing Fang,
Pravesh Gupta,
Waldemar Priebe,
Rafał Zieliński,
Jared K. Burks,
James P. Long,
Ling Yuan Kong,
Gregory N. Fuller,
John DeGroot,
Erik P. Sulman,
Amy B. Heimberger
Publication year - 2020
Publication title -
clinical cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.427
H-Index - 324
eISSN - 1557-3265
pISSN - 1078-0432
DOI - 10.1158/1078-0432.ccr-19-4092
Subject(s) - immune system , tumor microenvironment , cancer research , glioma , dendritic cell , medicine , angiogenesis , immunotherapy , t cell , immunology
Patients with central nervous system (CNS) tumors are typically treated with radiotherapy, but this is not curative and results in the upregulation of phosphorylated STAT3 (p-STAT3), which drives invasion, angiogenesis, and immune suppression. Therefore, we investigated the combined effect of an inhibitor of STAT3 and whole-brain radiotherapy (WBRT) in a murine model of glioma.