Open AccessResveratrol Selectively Induces DNA Damage, Independent of Smad4 Expression, in Its Efficacy against Human Head and Neck Squamous Cell Carcinoma
Author(s) -
Alpna Tyagi,
Mallikarjuna Gu,
Takenori Takahata,
Barbara Frederick,
Chapla Agarwal,
Sunitha Siriwardana,
Rajesh Agarwal,
Robert A. Sclafani
Publication year - 2011
Publication title -
clinical cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.427
H-Index - 324
eISSN - 1557-3265
pISSN - 1078-0432
DOI - 10.1158/1078-0432.ccr-11-1072
Subject(s) - resveratrol , head and neck squamous cell carcinoma , dna damage , head and neck , cancer research , dna , cell , basal cell , head and neck cancer , medicine , oncology , cancer , biology , pharmacology , genetics , surgery
Alterations in Smad4 signaling and its loss cause genomic instability and head and neck squamous cell carcinoma (HNSCC), suggesting that agents that target both Smad4-dependent and -independent pathways could control HNSCC.
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