Different Prognostic Roles of Mutations in the Helical and Kinase Domains of the PIK3CA Gene in Breast Carcinomas | Zendy

Mattia Barbareschi | Zendy; Fiamma Buttitta | Zendy; Lara Felicioni | Zendy; Sabrina Cotrupi | Zendy; Fabio Barassi | Zendy; Maela Del Grammastro | Zendy; Antonella Ferro | Zendy; Paolo Palma | Zendy; Enzo Galligioni | Zendy; Antonio Marchetti | Zendy

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Different Prognostic Roles of Mutations in the Helical and Kinase Domains of the PIK3CA Gene in Breast Carcinomas

Author(s) -

Mattia Barbareschi,

Fiamma Buttitta,

Lara Felicioni,

Sabrina Cotrupi,

Fabio Barassi,

Maela Del Grammastro,

Antonella Ferro,

Paolo Palma,

Enzo Galligioni,

Antonio Marchetti

Publication year - 2007

Publication title -

clinical cancer research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.427

H-Index - 324

eISSN - 1557-3265

pISSN - 1078-0432

DOI - 10.1158/1078-0432.ccr-07-0266

Subject(s) - exon , missense mutation , mutation , breast cancer , biology , univariate analysis , cancer research , gene , carcinoma , medicine , genetics , pathology , cancer , multivariate analysis

In breast cancer, the PIK3CA gene is frequently mutated at "hotspots" in exons 9 and 20, corresponding to the helical and kinase domains, respectively. We decided to investigate the association of PIK3CA mutations with pathologic features and clinical outcome in a large series of patients with breast cancer.

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