Open AccessSevere hyperthermia due to oral baclofen withdrawal
Author(s) -
Vishesh Paul,
Kari Righter,
Elise Kim,
Weston Nadherny
Publication year - 2020
Publication title -
bmj case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.231
H-Index - 26
ISSN - 1757-790X
DOI - 10.1136/bcr-2020-234710
Subject(s) - baclofen , medicine , sepsis , anesthesia , hyperthermia , differential diagnosis , surgery , pathology , agonist , receptor
We report a case of a 53-year-old woman who presented initially with sepsis and later in her stay developed a severe and rapidly progressing hyperthermia after a decrease in oral baclofen dosage. Her fever peaked at 42.5 ○ C (108.5 ○ F), creating a broad differential diagnosis and complicating her initial sepsis diagnosis. When the oral baclofen dose was increased, the fevers resolved which confirmed the clinical diagnosis of baclofen withdrawal. Dose reductions of oral baclofen should be made gradually and with caution, and patients should be monitored for fevers as a possible symptom of baclofen withdrawal.