Open AccessAcquisition and Processing of a Conditional Dicentric Chromosome in Saccharomyces cerevisiae
Author(s) -
A Hill,
Kerry Bloom
Publication year - 1989
Publication title -
molecular and cellular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.14
H-Index - 327
eISSN - 1067-8824
pISSN - 0270-7306
DOI - 10.1128/mcb.9.3.1368-1370.1989
Subject(s) - dicentric chromosome , biology , saccharomyces cerevisiae , centromere , genetics , chromosome , mitosis , aneuploidy , karyotype , gene
The introduction of a conditional centromere into chromosome III of Saccharomyces cerevisiae provided an opportunity to evaluate phenotypic and karyotypic consequences in cells harboring dicentric chromosomes upon entry into mitosis. A mitotic pause ensued, and monocentric derivatives of chromosome III were generated at a high frequency.