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Diazouracil (DZU) was shown to increase the mean cell volume of several bacterial species. The filaments which it induced withEscherichia coli B andLactobacillus casei were examined in section by electron microscopy. In addition to the inhibition of division ofE. coli by DZU, its effects were studied on mass increase, viability, and deoxyribonucleic acid, ribonucleic acid, and protein synthesis. The dependence of cell age on the division-inhibitory effect of DZU was examined in synchronous cultures. The division-inhibitory effect was not reversed by pantoyllactone, an antagonist of ultraviolet filamentation, or byl -tyrosine, which had been reported to antagonize DZU activity.

Growth-physiological Changes in Escherichia coli and Other Bacteria During Division Inhibition by 5-Diazouracil