Open AccessH-NS and RpoS regulate emergence of Lac Ara+ mutants of Escherichia coli MCS2
Author(s) -
José María Gómez-Gómez,
Jesús Blázquez,
Fernando Baquero,
José-Luis Martínez
Publication year - 1997
Publication title -
journal of bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.652
H-Index - 246
eISSN - 1067-8832
pISSN - 0021-9193
DOI - 10.1128/jb.179.14.4620-4622.1997
Subject(s) - rpos , biology , mutant , escherichia coli , sigma factor , lac operon , mutation , genetics , gene , microbiology and biotechnology , gene expression , promoter , rna polymerase
Two master growth-phase regulatory proteins, H-NS and sigmaS, are involved in the formation of araB-lacZ fusion clones of Escherichia coli MCS2. The stationary-phase sigma factor RpoS is strictly required for the appearance of such mutants, whereas the histone-like protein H-NS represses their emergence. Our results support the idea that genetic changes leading to adaptive mutation in this model system are regulated by physiological signal transduction networks.