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The regulation of several enzymes involved in one-carbon metabolism was studied in a mutant ofEscherichia coli K-12 defective inS -adenosylmethionine synthetase. The mutant that was reported to have a low endogenous concentration ofS -adenosylmethionine had elevated levels ofN -5, 10-methylene tetrahydrofolate reductase and serine transhydroxymethylase, but the level ofN -5, 10-methylene tetrahydrofolate dehydrogenase was not altered. These results suggest thatS -adenosylmethionine plays a role in the regulation of one-carbon production and utilization. An enzyme system that cleaved glycine to one-carbon units was demonstrated. The enzymes responsible for the cleavage of glycine were induced by exogenous glycine but were independent ofS -adenosylmethionine or purine levels in the cell.

Regulation of One-Carbon Biosynthesis and Utilization in Escherichia coli