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Genetic studies were undertaken on 14 pleiotropic negative sporulation mutants. These mutants (spoA ) which are blocked early in the sporulation process were found to map near the terminus of theBacillus subtilis chromosome in a region enriched in genes involved in spore formation. Two- and three-factor crosses by transduction and transformation led to the conclusion that the pleiotropicspoA mutations formed a linked cluster. The genetic distance across the cluster calculated from transformation data was compatible with the mutant sites defining a single gene. Suppressor studies revealed that either a nonsense or missense mutation in thespoA locus generated a pleiotropic negative phenotype. It was concluded that the locus codes for a protein, and the absence of this protein is responsible for the pleiotropic phenotype.

Genetic Analysis of Pleiotropic Negative Sporulation Mutants in Bacillus subtilis