English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Induction of penicillinase (β-lactamase) inBacillus licheniformis 749 by 2-(2′-carboxyphenyl)-benzoyl-6-aminopenicillanic acid (CBAP) was examined, since this compound was reported to be a gratuitous inducer of penicillinase inStaphylococcus aureus . The specific activity of enzyme optimally induced by CBAP is slightly more than that formed in response to cephalosporin C and threefold the level induced by benzylpenicillin. The optimal inducer concentration of CBAP was not inhibitory toward the growth of penicillinase-deficient mutants, unlike benzylpenicillin or cephalosporin C which showed marked toxicities. CBAP is hydrolyzed by theBacillus penicillinase, but as indicated by its “physiological efficiency” (V max /K m ), CBAP is a poor substrate at low concentrations. At very high concentrations, CBAP inhibited benzylpenicillin hydrolysis. The overall effectiveness of CBAP as an inducer can be attributed to its low “physiological efficiency” which enables the use of nontoxic levels of CBAP for induction without its rapid hydrolysis. Although CBAP is not a true gratuitous inducer, operationally it approaches gratuity for induction ofB. licheniformis penicillinase better than other known inducers.

journal of bacteriology

Penicillinase (β-Lactamase) Induction in <i>Bacillus licheniformis</i> Under Pseudogratuitous Conditions by 2-(2′-Carboxyphenyl)-Benzoyl-6-Aminopenicillanic Acid

Penicillinase (β-Lactamase) Induction in Bacillus licheniformis Under Pseudogratuitous Conditions by 2-(2′-Carboxyphenyl)-Benzoyl-6-Aminopenicillanic Acid