Open AccessMucosal Immunization with DTaP Confers Protection against Bordetella pertussis Infection and Cough in Sprague-Dawley Rats
Author(s) -
Joseph Hall,
Graham J. Bitzer,
Megan A. DeJong,
Jason Kang,
Ting Y. Wong,
Maximilian Wolf,
Justin R. Bevere,
Mariette Barbier,
F. Heath Damron
Publication year - 2021
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.00346-21
Subject(s) - bordetella pertussis , whooping cough , immunology , pertussis toxin , pertussis vaccine , immunization , biology , bordetella , virology , microbiology and biotechnology , vaccination , immune system , bacteria , g protein , receptor , biochemistry , genetics
Pertussis is a respiratory disease caused by the Gram-negative pathogen,Bordetella pertussis . The transition from a whole-cell pertussis vaccine (wP and DTP) to an acellular pertussis vaccine (aP, DTaP, and Tdap) correlates with an increase in pertussis cases, despite widespread vaccine implementation and coverage, and it is now appreciated that the protection provided by aP rapidly wanes.