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To control the pH during antimicrobial peptide (nisin) production by a lactic acid bacterium,Lactococcus lactis subsp.lactis (ATCC11454), a novel method involving neither addition of alkali nor a separation system such as a ceramic membrane filter and electrodialyzer was developed. A mixed culture ofL. lactis andKluyveromyces marxianus , which was isolated from kefir grains, was utilized in the developed system. The interaction between lactate production byL. lactis and its assimilation byK. marxianus was used to control the pH. To utilize the interaction of these microorganisms to maintain high-level production of nisin, the kinetics of growth of, and production of lactate, acetate, and nisin by,L. lactis were investigated. The kinetics of growth of and lactic acid consumption byK. marxianus were also investigated. Because the pH of the medium could be controlled by the lactate consumption ofK. marxianus and the specific lactate consumption rate ofK. marxianus could be controlled by changing the dissolved oxygen (DO) concentration, a cascade pH controller coupled with DO control was developed. As a result, the pH was kept constant because the lactate level was kept low and nisin accumulated in the medium to a high level compared with that attained using other pH control strategies, such as with processes lacking pH control and those in which pH is controlled by addition of alkali.

Nisin Production by a Mixed-Culture System Consisting of Lactococcus lactis and Kluyveromyces marxianus