The Gammaherpesvirus Chemokine Binding Protein Binds to the N Terminus of CXCL8 | Zendy

Louise M. C. Webb | Zendy; Ian ClarkLewis | Zendy; Antonio Alcamı́ | Zendy

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The Gammaherpesvirus Chemokine Binding Protein Binds to the N Terminus of CXCL8

Author(s) -

Louise M. C. Webb,

Ian ClarkLewis,

Antonio Alcamı́

Publication year - 2003

Publication title -

journal of virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.617

H-Index - 292

eISSN - 1070-6321

pISSN - 0022-538X

DOI - 10.1128/jvi.77.15.8588-8592.2003

Subject(s) - chemokine receptor , biology , ccr1 , xcl2 , chemokine , interleukin 8 , c c chemokine receptor type 6 , ccl21 , ccl25 , cxc chemokine receptors , receptor , chemokine receptor ccr5 , microbiology and biotechnology , chemotaxis , biochemistry , immunology , inflammation

Viruses encode proteins that disrupt chemokine responses. The murine gammaherpesvirus 68 gene M3 encodes a chemokine binding protein (vCKBP-3) which has no sequence similarity to chemokine receptors but inhibits chemokine receptor binding and activity. We have used a panel of CXCL8 analogs to identify the structural requirements for CXCL8 to bind to vCKBP-3 in a scintillation proximity assay. Our data suggest that vCKBP-3 acts by mimicking the binding of chemokine receptors to CXCL8.

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