Serotypic analysis of VP3 and VP7 neutralization escape mutants of rhesus rotavirus | Zendy

Robert D. Shaw | Zendy; Erich R. Mackow | Zendy; Mike DyallSmith | Zendy; I. Lazdins | Zendy; Ian Holmes | Zendy; Harry B. Greenberg | Zendy

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Serotypic analysis of VP3 and VP7 neutralization escape mutants of rhesus rotavirus

Author(s) -

Robert D. Shaw,

Erich R. Mackow,

Mike DyallSmith,

I. Lazdins,

Ian Holmes,

Harry B. Greenberg

Publication year - 1988

Publication title -

journal of virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.617

H-Index - 292

eISSN - 1070-6321

pISSN - 0022-538X

DOI - 10.1128/jvi.62.9.3509-3512.1988

Subject(s) - neutralization , virology , biology , rotavirus , mutant , epitope , hemagglutination , hemagglutination assay , antibody , virus , microbiology and biotechnology , immunology , genetics , gene , titer

Neutralization escape mutants of simian rotaviruses (rhesus rotavirus and SA11) were tested in hemagglutination inhibition and neutralization assays against hyperimmune and infection sera to determine if mutation in an immunodominant epitope could enable neutralization escape. An SA11 mutant with a new glycosylation site at amino acid 211 of VP7 was shown to escape neutralization by hyperimmune but not infection sera.

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