Naturally Occurring Human Monoclonal Antibodies Neutralize both 1918 and 2009 Pandemic Influenza A (H1N1) Viruses | Zendy

Jens C. Krause | Zendy; Terrence M. Tumpey | Zendy; Chelsey J. Huffman | Zendy; Patricia McGraw | Zendy; Melissa B. Pearce | Zendy; Tshidi Tsibane | Zendy; Rong Hai | Zendy; Christopher F. Basler | Zendy; James E. Crowe | Zendy

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Naturally Occurring Human Monoclonal Antibodies Neutralize both 1918 and 2009 Pandemic Influenza A (H1N1) Viruses

Author(s) -

Jens C. Krause,

Terrence M. Tumpey,

Chelsey J. Huffman,

Patricia McGraw,

Melissa B. Pearce,

Tshidi Tsibane,

Rong Hai,

Christopher F. Basler,

James E. Crowe

Publication year - 2009

Publication title -

journal of virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.617

H-Index - 292

eISSN - 1070-6321

pISSN - 0022-538X

DOI - 10.1128/jvi.02184-09

Subject(s) - virology , biology , monoclonal antibody , hemagglutinin (influenza) , pandemic , virus , h5n1 genetic structure , influenza a virus , antigenic drift , antibody , orthomyxoviridae , hypervariable region , antigen , microbiology and biotechnology , covid-19 , immunology , infectious disease (medical specialty) , medicine , disease , pathology

The 2009 pandemic influenza A (H1N1) virus exhibits hemagglutinin protein sequence homology with the 1918 pandemic influenza virus. We found that human monoclonal antibodies recognized the Sa antigenic site on the head domains of both 1918 and 2009 hemagglutinins, a site that is hypervariable due to immune selection. These antibodies exhibited high potency against the 2009 virus in vitro, and one exerted a marked therapeutic effect in vivo.

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