Open AccessMycobacterium tuberculosis Can Utilize Heme as an Iron Source
Author(s) -
Christopher M. Jones,
Michael Niederweis
Publication year - 2011
Publication title -
journal of bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.652
H-Index - 246
eISSN - 1067-8832
pISSN - 0021-9193
DOI - 10.1128/jb.01312-10
Subject(s) - heme , biology , mycobacterium tuberculosis , tuberculosis , microbiology and biotechnology , bacterial protein , bacteria , biochemistry , genetics , enzyme , pathology , medicine
Most iron in mammals is found within the heme prosthetic group. Consequently, many bacterial pathogens possess heme acquisition systems to utilize iron from the host. Here, we demonstrate thatMycobacterium tuberculosis can utilize heme as an iron source, suggesting thatM. tuberculosis possesses a yet-unknown heme acquisition system.
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