Open AccessInterleukin 1 production by peripheral blood mononuclear cells from leprosy patients
Author(s) -
Susan R. Watson,
Ward E. Bullock,
Kenrad E. Nelson,
Victoria Schauf,
R H Gelber,
Raymond L. Jacobson
Publication year - 1984
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.45.3.787-789.1984
Subject(s) - peripheral blood mononuclear cell , lepromatous leprosy , leprosy , tuberculoid leprosy , immunology , biology , interleukin , lipopolysaccharide , cytokine , in vitro , biochemistry
Quantitation of interleukin 1 production by adherent mononuclear cells from peripheral blood was performed in patients with tuberculoid and lepromatous forms of leprosy. Cells from patients with tuberculoid leprosy either secreted interleukin 1 spontaneously or produced amounts within the normal range in response to lipopolysaccharide stimulation. Conversely, stimulated cells from lepromatous patients failed to produce interleukin 1 in 5 of 13 (38.5%) cases.
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