Open AccessMechanism of Action of 4-Phenoxyphenoxyethyl Thiocyanate (WC-9) against Trypanosoma cruzi , the Causative Agent of Chagas’ Disease
Author(s) -
Julio A. Urbina,
Juan Luís Concepción,
Andrea Montalvetti,
Juan B. Rodríguez,
Roberto Docampo
Publication year - 2003
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.47.6.2047-2050.2003
Subject(s) - trypanosoma cruzi , chagas disease , biology , thiocyanate , mechanism of action , biochemistry , pharmacology , microbiology and biotechnology , chemistry , parasite hosting , virology , in vitro , world wide web , computer science
We investigated the molecular basis of the activity of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the etiological agent of Chagas' disease. We found that growth inhibition of T. cruzi epimastigotes induced by this compound was associated with a reduction in the content of the parasite's endogenous sterols due to a specific blockade of their de novo synthesis at the level of squalene synthase.
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