Inactivation of rifampin by Nocardia brasiliensis | Zendy

Kazunaga Yazawa | Zendy; Yoshinori Mikami | Zendy; Akio Maeda | Zendy; Mitsutaro Akao | Zendy; Naoko Morisaki | Zendy; Shintaro Iwasaki | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Inactivation of rifampin by Nocardia brasiliensis

Author(s) -

Kazunaga Yazawa,

Yoshinori Mikami,

Akio Maeda,

Mitsutaro Akao,

Naoko Morisaki,

Shintaro Iwasaki

Publication year - 1993

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.37.6.1313

Subject(s) - nocardia brasiliensis , nocardia , microbiology and biotechnology , bacteria , biology , nocardiaceae , antibiotics , antimicrobial , rifamycin , actinomycetales , rifampicin , nocardiosis , streptomyces , genetics

Rifampin was glycosylated by a pathogenic species of Nocardia, i.e., Nocardia brasiliensis. The structures of two glycosylated compounds (RIP-1 and RIP-2) isolated from the culture broth of the bacterium were determined to be 3-formyl-23-(O-[beta-D-glucopyranosyl])rifamycin SV and 23-(O-[beta-D-glucopyranosyl])rifampin, respectively. Both compounds lacked antimicrobial activity against other gram-positive bacteria as well as the Nocardia species.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research