Impact of Cefepime Susceptible-Dose-Dependent MIC for Enterobacteriaceae on Reporting and Prescribing | Zendy

Christina G. Rivera | Zendy; Prasanna P. Narayanan | Zendy; Robin Patel | Zendy; Lynn L. Estes | Zendy

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Impact of Cefepime Susceptible-Dose-Dependent MIC for Enterobacteriaceae on Reporting and Prescribing

Author(s) -

Christina G. Rivera,

Prasanna P. Narayanan,

Robin Patel,

Lynn L. Estes

Publication year - 2016

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00442-16

Subject(s) - cefepime , enterobacteriaceae , microbiology and biotechnology , cephalosporin , enterobacteriaceae infections , escherichia coli , medicine , biology , antibiotics , antibiotic resistance , imipenem , biochemistry , gene

The CLSI cefepime breakpoints were revised to include a susceptible-dose-dependent (SDD) category forEnterobacteriaceae , with the intention that higher cefepime doses be used for these isolates. In this study, 1.6% ofEnterobacteriaceae isolates were reported as SDD, withEscherichia coli the most common SDD organism. Cefepime was prescribed in three cases (4.8%); the majority of SDD isolates were treated with a carbapenem.Enterobacteriaceae with cefepime SDD MICs were not commonly treated with cefepime at our institution.

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