Open AccessIntegron-Derived Aminoglycoside-Sensing Riboswitches Control Aminoglycoside Acetyltransferase Resistance Gene Expression
Author(s) -
Shasha Wang,
Weizhi He,
Wenxia Sun,
Jun Zhang,
YaoWen Chang,
Dongrong Chen,
Alastair I.H. Murchie
Publication year - 2019
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.00236-19
Subject(s) - integron , aminoglycoside , acetyltransferase , gene , biology , genetics , chloramphenicol acetyltransferase , promoter , gene expression , plasmid , antibiotics , acetylation
Class 1 integrons accumulate antibiotic resistance genes by site-specific recombination ataatI-1 sites. Captured genes are transcribed from a promoter located within the integron; for class 1 integrons, the first gene to be transcribed and translated normally encodes an aminoglycoside antibiotic resistance protein (either an acetyltransferase [AAC] or adenyltransferase [AAD]).
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