Regulation of autophagy, NF-κB signaling, and cell viability by miR-124 in KRAS mutant mesenchymal-like NSCLC cells | Zendy

Anita K. Mehta | Zendy; Kevin Hua | Zendy; William J. Whipple | Zendy; Minh-Thuy Nguyen | Zendy; Yongmei Liu | Zendy; Johannes Haybaeck | Zendy; Joanne B. Weidhaas | Zendy; Jeff Settleman | Zendy; Anurag Singh | Zendy

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Regulation of autophagy, NF-κB signaling, and cell viability by miR-124 in KRAS mutant mesenchymal-like NSCLC cells

Author(s) -

Anita K. Mehta,

Kevin Hua,

William J. Whipple,

Minh-Thuy Nguyen,

Yongmei Liu,

Johannes Haybaeck,

Joanne B. Weidhaas,

Jeff Settleman,

Anurag Singh

Publication year - 2017

Publication title -

science signaling

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.659

H-Index - 154

eISSN - 1937-9145

pISSN - 1945-0877

DOI - 10.1126/scisignal.aam6291

Subject(s) - becn1 , biology , kras , mesenchymal stem cell , cancer research , microrna , epithelial–mesenchymal transition , autophagy , ubiquitin ligase , signal transduction , microbiology and biotechnology , cancer , apoptosis , ubiquitin , metastasis , colorectal cancer , gene , genetics

The loss of microRNA miR-124 enables prosurvival autophagy signaling and metastatic features inKRAS mutant mesenchymal lung cancer cells.

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