Electrical stimulation of the vagus increases extracellular glutamate recovered from the nucleus tractus solitarii of the cat by in vivo microdialysis | Zendy

Allchin RE | Zendy; Batten TF | Zendy; McWilliam PN | Zendy; Vaughan PF | Zendy

Premium

Electrical stimulation of the vagus increases extracellular glutamate recovered from the nucleus tractus solitarii of the cat by in vivo microdialysis

Author(s) -

Allchin RE,

Batten TF,

McWilliam PN,

Vaughan PF

Publication year - 1994

Publication title -

experimental physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.925

H-Index - 101

eISSN - 1469-445X

pISSN - 0958-0670

DOI - 10.1113/expphysiol.1994.sp003761

Subject(s) - microdialysis , stimulation , in vivo , nucleus , extracellular , vagus nerve , glutamate receptor , neuroscience , solitary nucleus , chemistry , biology , biochemistry , microbiology and biotechnology , receptor

Release of glutamate into the extracellular space of the cat nucleus tractus solitarii (NTS) was measured by in vivo microdialysis and high performance liquid chromatography. Perfusion of the probe with 100 mM potassium increased glutamate release by 211% (P < 0.001), while electrical stimulation of the cervical vagus increased release by 53% (P < 0.01). These results are compatible with the hypothesis that glutamate is a neurotransmitter released by vagal afferent nerve terminals in the NTS.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research