Open AccessLung transplantation from uncontrolled and controlled donation after circulatory death: similar outcomes to brain death donors
Author(s) -
CampoCañaveral de la Cruz Jose Luis,
Crowley Carrasco Silvana,
Tanaka Shin,
Romero Román Alejandra,
Hoyos Mejía Lucas,
Gil Barturen Mariana,
Sánchez Calle Álvaro,
García Fadul Christian,
Aguilar Pérez Myriam,
Pérez Redondo Marina,
Naranjo Gómez Jose Manuel,
Royuela Ana,
Córdoba Peláez Mar,
Varela de Ugarte Andrés,
Gómez de Antonio David
Publication year - 2021
Publication title -
transplant international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.998
H-Index - 82
eISSN - 1432-2277
pISSN - 0934-0874
DOI - 10.1111/tri.14120
Subject(s) - medicine , extracorporeal membrane oxygenation , donation , lung transplantation , univariate analysis , transplantation , organ donation , retrospective cohort study , circulatory system , multivariate analysis , surgery , economics , economic growth
Summary Controlled donation after circulatory death donors (cDCD) are becoming a frequent source of lungs grafts worldwide. Conversely, lung transplantations (LTx) from uncontrolled donors (uDCD) are sporadically reported. We aimed to review our institutional experience using both uDCD and cDCD and compare to LTx from brain death donors (DBD). This is a retrospective analysis of all LTx performed between January 2013 and December 2019 in our institution. Donor and recipient characteristics were collected and univariate, multivariate and survival analyses were carried out comparing the three cohorts of donors. A total of 239 (84.7%) LTx were performed from DBD, 29 (10.3%) from cDCD and 14 (5%) from uDCD. There were no statistically significant differences in primary graft dysfunction grade 3 at 72 h, 30‐ and 90‐day mortality, need for extracorporeal membrane oxygenation after procedure, ICU and hospital length of stay, airway complications, CLAD incidence or survival at 1 and 3 years after transplant (DBD: 87.1% and 78.1%; cDCD: 89.7% and 89.7%; uDCD: 85.7% and 85.7% respectively; P = 0.42). Short‐ and mid‐term outcomes are comparable between the three types of donors. These findings may encourage and reinforce all types of donation after circulatory death programmes as a valid and growing source of suitable organs for transplantation.