Modern‐day management of upper gastrointestinal haemorrhage | Zendy

Jairath V. | Zendy; Desborough M. J. R. | Zendy

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Modern‐day management of upper gastrointestinal haemorrhage

Author(s) -

Jairath V.,

Desborough M. J. R.

Publication year - 2015

Publication title -

transfusion medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.471

H-Index - 59

eISSN - 1365-3148

pISSN - 0958-7578

DOI - 10.1111/tme.12266

Subject(s) - medicine , etiology , blood transfusion , intensive care medicine , cirrhosis , tranexamic acid , upper gastrointestinal bleeding , fibrinogen , blood loss , surgery , endoscopy

SUMMARY Acute upper gastrointestinal haemorrhage ( AUGIH ) is a common medical emergency and can present with life threatening haemorrhage. In the UK , there are 70 000 hospital admissions per year. In the majority of cases, the aetiology is non‐variceal in origin, but in other cases it is due to variceal bleeding in patients with cirrhosis. It is also a leading indication for transfusion of blood components. This review explores recent randomised data on the efficacy and safety of red blood cell transfusion for AUGIH . In addition, the evidence base for use of other blood components and pro‐haemostatic pharmacological agents is discussed, including acid suppression, antifibrinolytics and fibrinogen.

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