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Immunogenicity and side‐effects of the inactivated hepatitis A vaccine in periodic fever, aphthous stomatitis, pharyngitis, and adenitis patients
Author(s) -
Maritsi Despoi,
Syrmou Areti,
Vartzelis George,
Diamantopoulos Stavros,
Tsolia Maria N
Publication year - 2019
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/ped.13719
Subject(s) - medicine , pharyngitis , immunogenicity , hepatitis a vaccine , seroconversion , vaccination , stomatitis , adverse effect , adenitis , immunology , gastroenterology , dermatology , antibody
Abstract The aim of this study was to compare the immunogenicity and side‐effects of hepatitis A virus ( HAV ) vaccination between periodic fever, aphthous stomatitis, pharyngitis, and adenitis ( PFAPA ) patients and healthy controls who have not been previously exposed to HAV . A prospective observational study was carried out of 28 PFAPA patients and 76 controls who received two doses of the vaccine. Immunogenicity was expressed as seroconversion and seroprotection rates; mean HAV ‐immunoglobulin G concentration was measured at 0, 1, 7 and 18 months. Side‐effects were defined as incidence of adverse events and the effect of vaccination on PFAPA symptoms. All participants were seronegative and seroconverted at 1 month. One month after primary vaccination, 92.9% of PFAPA patients and 77.6% of the controls attained seroprotection, while the rates increased to 100% and 96.1%, respectively, 1 month after the second dose. Seroprotection rates remained adequate 1 year after completion of vaccination. In conclusion, two doses of the inactivated HAV vaccine are well‐tolerated and effective in children with PFAPA .