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Development and validation of the K ‐ VSCOR for scoring K oebner's phenomenon in v itiligo/non‐segmental vitiligo
Author(s) -
Diallo Abou,
Boniface Katia,
Jouary Thomas,
Seneschal Julien,
MoricePicard Fanny,
Prey Sorilla,
CarioAndré Muriel,
MazereeuwHautier Juliette,
Taieb Alain,
Ezzedine Khaled
Publication year - 2013
Publication title -
pigment cell and melanoma research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.618
H-Index - 105
eISSN - 1755-148X
pISSN - 1755-1471
DOI - 10.1111/pcmr.12065
Subject(s) - vitiligo , forehead , medicine , scalp , dermatology , population , clinical practice , surgery , physical therapy , environmental health
Summary The relation of v itiligo/non‐segmental vitiligo ( NSV ) to K oebner's phenomenon is variably appreciated. Our objective was to develop and validate a simple clinical score for K oebner's phenomenon ( KP ) in patients with vitiligo/ NSV . The study population was composed of 351 individuals in the development sample and 285 patients in the validation sample. Seven variables were independently associated with the presence of KP : disease duration of more than 3 yr, forehead + scalp areas, eyelids, wrists, genital + belt areas, knees and tibial crests. The score computed by the weighted sum of the rounded coefficients of these seven variables ranged from 0 to 56 (mean 38.39 ± 22.93). The probability of having KP was computed as follows: exp (−2.37 + 0.1*score)/exp [1 + (−2.37 + 0.1*score)]. When applying the score to each patient in the validation and the development sample, the score maintained adequate discrimination and calibration ( AUC ‐ ROC = 0.78), arguing that KP can be adequately predicted using our score. Further studies should evaluate KP assessed by the K ‐ VSCOR in clinical practice with the aim to determine its association with clinical profile, course and treatment response of vitiligo.