Peanut oral immunotherapy increases IgG4 to Ara h 1, 2, and 6 but does not affect IgG4 to other allergens

Life-threatening allergic reactions are characterized by allergen-specific IgE antibodies, whereas IgG antibodies are a default response to an antigen exposure. Subclass 4 IgG antibodies function as blocking antibodies, which may suppress IgE-mediated reactions. Peanut oral immunotherapy (OIT), as other allergen immunotherapies, induces IgG4 antibodies. We have previously shown the increase of IgG4 to peanut seed storage proteins, and the dose-dependent increase of IgG4- IgE ratios in children and adolescents receiving peanut OIT. This article is protected by copyright. All rights reserved.