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Medication‐related osteonecrosis of the jaw – a current review
Author(s) -
Domah F.,
Shah N.,
Domah J.,
Shah R.
Publication year - 2018
Publication title -
oral surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.156
H-Index - 11
eISSN - 1752-248X
pISSN - 1752-2471
DOI - 10.1111/ors.12329
Subject(s) - medicine , osteonecrosis of the jaw , action (physics) , intensive care medicine , dentistry , pathology , bisphosphonate , osteoporosis , physics , quantum mechanics
Abstract Aim This study was aimed to discuss different classes of antiresorptive agents and their modes of action, to review the proposed mechanisms in the pathophysiology of osteonecrosis development and to analyse the prevention and the management of medication‐related osteonecrosis of the jaw. Materials and methods Three databases were searched for relevant articles: PubMed, Ovid and Dentistry and Oral Sciences Source. Current literature consists mainly of case series, case reports and expert body opinions. Discussion The repertoire of antiresorptive medication keeps expanding as novel drugs are being introduced. The exact pathway that leads to the development of osteonecrosis remains to be elucidated, but different mechanisms have been put forward. An attempt at staging has been made, and treatment guidelines have been drawn but opinions remain divided. New treatments are being trialled; however, evidence is lacking.