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Rivaroxaban does not affect growth of human pancreatic tumors in mice
Author(s) -
Maqsood Anaum,
Hisada Yohei,
Garratt Kenison B.,
Homeister Jonathon,
Mackman Nigel
Publication year - 2019
Publication title -
journal of thrombosis and haemostasis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.947
H-Index - 178
eISSN - 1538-7836
pISSN - 1538-7933
DOI - 10.1111/jth.14604
Subject(s) - rivaroxaban , pancreatic cancer , medicine , endocrinology , pancreatic tumor , cancer research , cancer , warfarin , atrial fibrillation
Abstract Background Some clinical studies have shown that low‐molecular‐weight heparins (LMWHs) prolong the survival of cancer patients. In addition, various anticoagulants have been shown to reduce growth of tumors in mice. However, there are no studies on the effect of the factor Xa inhibitor rivaroxaban on growth of human pancreatic tumors in nude mice. Objectives To test the hypothesis that the factor Xa inhibitor rivaroxaban reduces the growth of tissue factor ( TF )‐positive pancreatic tumors but not TF ‐negative pancreatic tumors in mice. Methods The TF ‐positive human pancreatic cancer cell line BxPc‐3 and the TF ‐negative human pancreatic cancer cell line MIA PaCa‐2 were injected subcutaneously into nude mice and tumors grown to a mean volume of ~100 mm 3 . Mice were then divided into two groups. One group was fed chow containing rivaroxaban (0.5 g/kg chow) whereas the other group was fed chow without rivaroxaban. Results Rivaroxaban significantly prolonged prothrombin time in tumor‐bearing mice. Rivaroxaban did not affect cell proliferation or growth of either BxPc‐3 or MIA PaCa‐2 tumors grown subcutaneously in nude mice. Conclusion Our results indicate that inhibition of factor Xa with rivaroxaban does not affect the growth of two human pancreatic tumors in nude mice.